physiochemical characterization and release rate studies of solid dispersions of ketoconazole with pluronic f127 and pvp k-30

نویسندگان

pankaj kumar department of pharmaceutical sciences, lovely professional university, chaharu, phagwara, punjab-144402, india.

chander mohan rayat college of pharmacy, hoshiarpur, punjab, india.

mara kanam srinivasan uma shankar department of pharmaceutical sciences, lovely professional university, chaharu, phagwara, punjab-144402, india.

monica gulati department of pharmaceutical sciences, lovely professional university, chaharu, phagwara, punjab-144402, india.

چکیده

in the present study solid dispersions of the antifungal drug ketoconazole were prepared with pluronic f-127 and pvp k-30 with an intention to improve its dissolution properties. investigations of the properties of the dispersions were performed using release studies, differential scanning calorimetery (dsc), x-ray powder diffraction (xrd) and fourier transform infrared (ftir). the results obtained showed that the rate of dissolution of ketoconazole was considerably improved when formulated in solid dispersions with pvp k-30 and pluronic f-127 as compared with pure drug and physical mixtures. the results from dsc and xrd studies showed the transition of crystalline nature of drug to amorphous form, while ftir studies demonstrated the absence of drug-carriers interaction.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Physiochemical Characterization and Release Rate Studies of Solid Dispersions of Ketoconazole with Pluronic F127 and PVP K-30

In the present study solid dispersions of the antifungal drug Ketoconazole were prepared with Pluronic F-127 and PVP K-30 with an intention to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, Differential scanning calorimetery (DSC), X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obta...

متن کامل

Physiochemical Characterization and Release Rate Studies of Solid Dispersions of Ketoconazole with Pluronic F127 and PVP K-30

In the present study solid dispersions of the antifungal drug Ketoconazole were prepared with Pluronic F-127 and PVP K-30 with an intention to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, Differential scanning calorimetery (DSC), X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obta...

متن کامل

Physiochemical Characterization and Release Rate Studies of SolidDispersions of Ketoconazole with Pluronic F127 and PVP K-30

In the present study solid dispersions of the antifungal drug Ketoconazole were prepared with Pluronic F-127 and PVP K-30 with an intention to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, Differential scanning calorimetery (DSC), X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obta...

متن کامل

Physicochemical Characterization and Dissolution Studies of Solid Dispersions of Clotrimazole with Pluronic F127

Purpose: To evaluate the physicochemical properties of clotrimazole (CLT) solid dispersion with Pluronic F127 (PLU). Methods: Solid dispersions of the antifungal drug, clotrimazole, were prepared with Pluronic F127 using grinding (PM) and fusion (FUS) methods. Physicochemical characterization of the dispersions were performed using differential scanning calorimetry (DSC), x-ray powder diffracti...

متن کامل

Solubilization and Solid-State Characterization of Modafinil Solid Dispersions using PVP K 30

The objective of the present study was to improve the dissolution rate of Modafinil by solid dispersion (SD) systems in PVP-K 30. Drug contents were determined by UV Spectrophotometry at λmax of 259.5 nm. The phase solubility behavior of Modafinil in presence of various concentrations of carriers in distilled water was obtained at 37±2C. The dissolution of Modafinil increased with increasing am...

متن کامل

Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method.

The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at different drug-to-polymer ratios. The obtained physical mixtures and solid dispersions were examined in terms of drug content and possible physical and chemical interactions between the drug and polymer using...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۲۰۱۱، شماره ۴، صفحات ۶۸۵-۶۹۴

کلمات کلیدی
[ ' s o l i d d i s p e r s i o n ' , ' k e t o c o n a z o l e ' , ' p v p k ' , 3 0 , ' p l u r o n i c f 1 2 7 ' , ' s o l v e n t e v a p o r a t i o n ' , ' m e l t ' , ' f u s i o n ' ]

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023